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בית הספר לרוקחות
Academic Staff Prof. Elka Touitou סגל אקדמי
   Personal Details       Research Interest       Research Projects       Journal Articles       Books edited       Book Chapters       Patents       Industry       Honors   

Personal details:
Academic Rank: Prof.
Phone: 972-2-6758660
Fax 972-2-6757611
Email: touitou@cc.huji.ac.il
Room no.: 305


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Research Interest:

Dermal and transdermal drug delivery: enhancers and mechanism of action, enhanced delivery of peptides and other drugs through biological membranes

Nasal drug delivery for systemic action

New CNS therapies

Systems for prevention and regeneration of burn injury

Novel approaches for enhanced and modulated delivery of peptides and drugs to/through the skin: ethosomes, eutectics, chiral drugs

Novel combined model for skin penetration with biological endpoint

Design and development of a new sunscreen non-penetrating the skin

 

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Research Projects:

Ethosomes: novel vesicular carriers for topical and transdermal delivery

Carriers for enhanced nasal absorption of therapeutic agents

Specially tailored carriers for topical anti-cancer therapy

Improved delivery of testosterone from novel transdermal systems: testosome patch and gel

New dermal therapeutic compositions for treatment of: acne, deep skin infections, alopecia, herpes simplex, cellulite

New transdermal delivery systems for treatment of: hypogonadism, erectile dysfunction, pain, inflammation, depression, rheumatic arthritis

New sanitizer concept and compositions



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Journal Articles:

Shumilov M, Touitou E

Buspirone transdermal administration for menopausal syndromes, in vitro and in animal model studies.

Int. J. Pharm., 2009, doi:10.1016/j.ijpharm.2009.11.029

 

Ainbinder D, Protokin R, Chaouat M, Touitou E

Effect of honokiol and 5-FU on non-melanoma skin cancer cells

J. Drug Del. Sci. Tech., 19 (4): 283-7, 2009

 

Shumilov M, Touitou E, Godin B, Ainbinder D, Yosha I, Tsahor-Ohayon H

Evaluation of a polysiloxane-collagen biphasic membrane: a model for in vitro skin permeation studies

J. Drug Del. Sci. Tech., 19 (4): 289-94, 2009

 

Touitou E, Godin B, Shumilov M, Bishouty N, Ainbinder D, Shouval R, Ingber A, Leibovici V

Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris.

J. Eur. Acad. Dermatol. Venereol. 22 (5): 629-31, 2008

 

Touitou E, Godin B

Skin nonpenetrating sunscreens for cosmetic and pharmaceutical formulations.

Clin. Dermatol. 26 (4): 375-9, 2008

 

Godin B, Touitou E

Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models.

Adv. Drug Deliv. Rev. 59 (11): 1152-61, 2007

 

Touitou E, Waknine JH, Godin B, Golenser J

Treatment of malaria in a mouse model by intranasal drug administration.

Int. J. Parasitol. 36 (14): 1493-8, 2006

 

Ainbinder D, Touitou E

Testosterone ethosomes for enhanced transdermal delivery.

Drug. Deliv. 12 (5): 297-303, 2005

 

Godin B, Touitou E, Rubinstein E, Athamna A, Athamna M

A new approach for treatment of deep skin infections by an ethosomal antibiotic preparation: an in vivo study.

J. Antimicrob. Chemother. 55 (6): 989-94, 2005

 

Godin B, Touitou E

Erythromycin ethosomal systems: physicochemical characterization and enhanced antibacterial activity.

Curr. Drug Deliv. 2 (3): 269-75, 2005

 

 

 

Godin B, Touitou E

Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier.

J. Control Release. 94 (2-3): 365-79, 2004

 

Touitou E, Lodzki M, Godin B, Rakou L, Mechoulam R, Gallily R

Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.

J. Control Release. 93 (3): 377-87, 2003

 

Godin B, Touitou E

Ethosomes: new prospects in transdermal delivery.

Crit. Rev. Ther. Drug Carrier Syst. 20 (1): 63-102, 2003

 

Touitou E

Drug delivery across the skin.

Expert Opin. Biol. Ther. 2 (7): 723-33, 2002

 

Touitou E, Godin B, Karl Y, Bujanover S, Becker Y

Oleic acid, a skin penetration enhancer, affects Langerhans cells and corneocytes.

J. Control Release. 80 (1-3): 1-7, 2002

 

Touitou E, Godin B, Dayan N, Weiss C, Piliponsky A, Levi-Schaffer F

Intracellular delivery mediated by an ethosomal carrier.

Biomaterials 22 (22): 3053-9, 2001

 

Evrard D, Touitou E, Kolusheva S, Fishov Y, Jelinek R

A new colorimetric assay for studying and rapid screening of membrane penetration enhancers.

Pharm. Res. 18 (7): 943-9, 2001

 

Meidan VM, Touitou E

Treatments for androgenetic alopecia and alopecia areata: current options and future prospects.

Drugs 61 (1): 53-69, 2001

 

Dayan N, Touitou E

Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes.

Biomaterials 21 (18): 1879-85, 2000

 

Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M

Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties.

J. Control Release 65 (3): 403-18, 2000

 

Levi-Schaffer F, Slovik D, Armetti L, Pickholtz D, Touitou E

Activation and inhibition of mast cells degranulation affect their morphometric parameters.

Life Sci. 66 (21): 283-90, 2000

 

 Horwitz E, Pisanty S, Czerninski R, Helser M, Eliav E, Touitou E

A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 87 (6): 700-5, 1999

 

Touitou E, Meidan VM, Horwitz E

Methods for quantitative determination of drug localized in the skin.

J Control Release 56 (1-3): 7-21, 1998

 

 

 

 

 

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Books edited:

Touitou, E. and Barry B.W. (Eds.) (2006)

Enhancement in Drug Delivery, CRC Press, Taylor & Francis Group, Boca Raton-London-New York.

 

Magdassi, S., Touitou, E. (Eds.) (1999)

Novel Cosmetic Delivery Systems, Marcel Dekker, Inc., New York.

 

 

 

 



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Book Chapters:

Ainbinder D., Touitou E.

Skin photodamage prevention: state of the art and new prospects.

In: Farage M.A., Miller K. W., Maibach H. I. (Eds) Textbook of Aging Skin, Springer-Verlag Berlin Heidelberg, 2010, DOI 10.1007/978-3-540-89656-2 44.

Godin B., Touitou E.
Nanoparticles aiming at specific targets - dermal and transdermal delivery.

In: Domb A. J., Tabata Y., Ravi Kumar M. N. V. (Eds) Nanoparticles for Pharmaceutical Applications, American Scientific Publishers, Valencia, 2007, pp. 192-211.

 

Godin B., Touitou E.
Surfactants in enhanced enteral delivery of macromolecules.
In: Touitou E., Barry BW. (Eds) Enhancement in drug delivery, CRC Press, Taylor & Francis Group, Boca Raton-London-New York, 2006, pp. 37-56.

Touitou E., Godin B.
Vesicles for enhanced delivery into and through the skin.
In: Touitou E., Barry BW. (Eds) Enhancement in drug delivery, CRC Press, Taylor & Francis Group, Boca Raton-London-New York, 2006, pp. 255-278.

Touitou, E., Godin, B.
Enhanced skin permeation using ethosomes.

In: Smith and Maibach (Eds) Percutaneous Penetration Enhancers, 2nd edition, CRC Press, New York, 2005, pp 95-108.

Touitou, E., Godin, B., Kommuru, T.R, Afouna, M.I., Reddy I.K.
Transport of chiral molecules across the skin.
In: Reddy and Mehvar (Eds) Chirality in drug design and development, Marcel Dekker, Inc., New York, 2003, pp. 67-99.

Magdassi, S., Touitou, E.
Cosmeceutics and Delivery Systems.
In: Magdassi and Touitou (Eds) Novel Cosmetic Delivery Systems, Marcel Dekker, Inc., New York, 1999, pp.1-9.

Meidan, V.M., Touitou, E.
Quantitation of penetrant molecules within the skin.
In: Novel Cosmetic Delivery Systems, Marcel Dekker, Inc., New York, 1999, pp. 131-144.

Touitou, E., Chow, D.D.
n-Decyl Methyl Sulphoxide.
In: Maibach and Smith (Eds) Skin Permeation Enhancers, CRC, New York, 1995, pp.103-113.

 

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Patents:

Touitou, E. Compositions for applying active substances to or through the skin

Touitou, E. Compositions and methods for intracellular delivery

Touitou, E., Bergelson, L. Products for preventing penetration into the skin

Touitou, E., Godin, B. In vitro test for predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound

Touitou E. Method and composition for burned skin

Touitou E., Godin B., Duchi S. Compositions for nasal delivery

 



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Industry:

Formulations and testing of dermal and transdermal products

Methods for quantitating drugs in the skin

Novel and generic dermal formulations

Use of ethosomes for design of topical and transdermal formulations of peptides, antivirals, antialopecia, others

Design of new carriers for topical compositions

Novel model for skin penetration and bioassay for Pharmalogica consortium, Magnet, Ministry of Industry, Israel

 



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Honors:

Awards:

      Best teacher of the year 2009

Kaye Award for Innovation (2006)

Jorge Heller 2000 JCR Outstanding Paper Award

Outstanding Paper Award – Drug Delivery to the 3rd Millennium Conference -

Italy (1999)

Honoree Women Pharmacist of the World (FIP 1998)

 

Professional Activities:

Reviewer of Scientific International Journals:  

Journal of Controlled Release
Pharmaceutical Research
Biomaterials
Journal of Pharmaceutical Sciences
Expert Opinion on Biological Therapy
Drugs & Aging
International Journal of Biological Macromolecules
European Journal of Pharmaceutical Sciences
International Journal of Pharmaceutics
S.T.P. Pharma Sciences
Drug Development and Industrial Pharmacy
Experimental Dermatology

 

Reviewer for International Institutional Grants:

Italian Ministry of Research and Universities
Arthritis Research Campaign (UK)
Research Founds Committee (FWF, Austria)
Ministry of Health (Israel)
Ministry of Agriculture (Israel)
Ministry of Science (Israel)
Binational Science Foundation (Israel-US)
ISF (Israel)

 

Public Responsibilities and Committees:

Public Representative, Appointment Committee (Ministry of Health)
Skin Bioavalability Committee (Ministry of Health)

Adviser Committee for Curriculum (ORT Givat-Ram High School, Jerusalem Municipality)

Committee for updating the Pharmaceutical Law, Ministry of Heath

Member of the Advisory Committee to the Ministry of Health for Cosmetic products registration, Israel

 

Committees at the Hebrew University:

Head of Teaching Committee, School of Pharmacy
Head of Students Scholarship Committee, School of Pharmacy
Head Appointment Committee Faculty of Medicine
Academic Committee of the School of Pharmacy
University Regulations Committee


Professional Honors:

Member at Large, Board of Directors, CRS

President – Israeli Chapter of CRS (ICRS)

Member of Awards Committee, CRS

Organizing Committee – Israeli Chapter of CRS (ICRS)

Board - Israeli Chapter of CRS (ICRS)

 

 



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School of Pharmacy HUJI logo האוניברסיטה העברית בירושלים הפקולטה לרפואה The Hebrew University of Jerusalem Faculty of Medicine