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1. Prof. Ioav Cabantchick, Hebrew University, Jerusalem
2. Prof. Michal Lineal,  Hebrew University, Jerusalem
3. Prof. Avraham Nudelman, Bar-Ilan University

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1. Genetics and proteomics of prenatal stress.
2. Rat behavioral tests: (a) Tests of Spatial and episodic memory; (b) Tests of anxiety and depressive activity.
3. In vivo and tissue culture models of neuronal damage involving oxidative stress.
4. Kinetic analysis of cholinesterase inhibition by aromatic carbamates.
5. Brain immunohistochemistry

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Groner E, Ashani Y, Schorer-Apelbaum D, Sterling J, Herzig Y, Weinstock M.

The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates.

Mol Pharmacol 2007, in press.

Yaka R, Salomon S, Matzner H, Weinstock M.

Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats. 

Behav Brain Res 2007, in press.

Bogoch Y, Biala YN, Linial M, Weinstock M.

Anxiety induced by prenatal stress is associated with suppression of hippocampal genes involved in synaptic function.

J Neurochem 2007, in press.

Shoham S, Bejar C, Kovalev E, Schorer-Apelbaum D, Weinstock M.

Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats.

Neuropharmacol 52: 836-843, 2007.

Murmu MS, Salomon S, Biala Y, Weinstock M, Braun K, Bock J.

Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy.

Eur J Neurosci 24: 1477-1487, 2006.

Zagron G, Weinstock M.

Maternal adrenal hormone secretion mediates behavioural alterations induced by prenatal stress in male and female rats.

Behav Brain Res 175:323-328, 2006.

Weinstock M, Luques L, Bejar C, Shoham S.

Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression.

J Neural Transm [Suppl] 70: 443-446, 2006.

Poltyrev T, Gorodetsky E, Bejar C, Schorer-Apelbaum D, Weinstock M.

Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic–pituitary–adrenal axis in male and female prenatally stressed rats.

Psychopharmacol 181: 118-125, 2005.

Beilin B, Bessler H, Papismedov L, Weinstock M, Shavit Y.

Continuous physostigmine combined with morphine-based patient-controlled analgesia in the postoperative period.

Acta Anaesthesiol. Scand. 49(1): 78-84, 2005.

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Weinstock M.

The potential influence of maternal stress hormones on development and mental health of the offspring. (invited review)

Brain Behav. Immunity 19: 296-308, 2005.

 

Weinstock, M.
Can the behavioral abnormalities induced by gestational stress in rats be prevented or reversed?
Stress 5: 167-176, 2002

 

Weinstock  M.

Alterations induced by gestational stress in brain morphology and behaviour of the offspring.
Prog Neurobiol.;65(5):427-51. Review. 2001/

Weinstock  M.

Effects of maternal stress on development and behaviour in rat offspring. (invited review)

Stress 4: 157-167, 2001.

 

Youdim, M. B.H. Weinstock, M.
Molecular basis of neuroprotective activities of rasagline and the anti-Alzheimer drug, TV3326, [ N-propargyl- 3R aminoindan-5-YL -ethyl methyl carbamate].
Cell. Mol Biol. 21: 555-573, 2001.

Weinstock, M., Goren, T., Youdim, M.B.H.
Development of a novel neuroprotective drug TV3326 for the treatment of Alzheimer’s Disease, with cholinesterase and monoamine oxidase inhibitory activities.
Drug Dev. Res. 50: 216-222, 2000.

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Patents:

1.  Phenylethylamine Derivatives: U.S patent No.US 6,251,938, B1: June 26 2001 

2.  Aminindan Derivatives: U.S patent No.US 6,303,650,  B1: Oct 16 2001

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